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December 8, 2025BloodOpen Access

Dissecting clonal hematopoiesis in diffuse large B-cell lymphoma through multi-compartment genomic profiling

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Authors

RBRiccardo BrunaRDRiccardo DondolinFMFrancesca Mercalli

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Overview

Observational study reveals clonal hematopoiesis prevalence in DLBCL, indicating links to mutations and disease molecular subtypes.

Key Points

  • Evaluate clonal hematopoiesis in diffuse large B-cell lymphoma using multi-compartment genomic profiling.
  • Analyzed 366 samples from 169 patients with newly diagnosed DLBCL
  • Used CAPP-Seq based NGS to assess mutations
  • Sample types included granulocytes, plasma cfDNA, and lymph node biopsies
  • 29.4% of the cohort displayed clonal hematopoiesis in the granulocyte compartment
  • Mutation in DNMT3A observed in 19.8% of cases
  • Higher prevalence of clonal hematopoiesis at baseline identified in 38.5% of plasma cfDNA cases

Cite This Study

Bruna et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e57bhttps://doi.org/10.1182/blood-2025-3537
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  5. 5Tumor-infiltrating clonal hematopoiesis is associated with adverse clinical outcomes in diffuse large B-cell lymphoma2026