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December 8, 2025Blood

Prognostic value of combining beta-2-microglobulin and total metabolic tumor volume in patients with follicular lymphoma: A post-hoc analysis of the relevance trial

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Authors

LYLoïc YsebaertRRRomain RicciDTDavid Tonnelet

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Overview

Post-hoc analysis shows prognostic value of beta-2-microglobulin and tumor volume in follicular lymphoma, suggesting improved risk stratification.

Key Points

  • To assess the prognostic value of a score combining beta-2-microglobulin and total metabolic tumor volume in follicular lymphoma patients.
  • Performed post-hoc analysis on data from the RELEVANCE trial
  • Used Cox models with penalized splines for variable assessment
  • Evaluated the prognostic performance of the combined score using discrimination and calibration metrics.
  • Combined model outperformed FLIPI, FLIPI2, and PRIMA-PI in prediction
  • Median progression-free survival was evaluated with a hazard ratio of 1.49 for B2M increase
  • Risk groups stratified showed significantly different outcomes for progression or death.

Cite This Study

Ysebaert et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db2bhttps://doi.org/10.1182/blood-2025-5361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total metabolic tumor volume as a prognostic biomarker in high-burden follicular lymphoma: A systematic review and meta-analysis2025
  2. 2Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.2026
  3. 3Prognosis prediction beyond MTV using easy to calculate parameters derived from FDG-PET/CT, a pilot Study2025
  4. 4Effect of FDG-PET–based bone marrow assessment on prognostic accuracy compared to conventional histologic evaluation in patients with follicular lymphoma: A subanalysis of the FIL FOLL12 trial.2026
  5. 5Prognostic Value of Combined Baseline FDG PET/CT Radiomic Parameters in Primary Mediastinal B-Cell Lymphoma2026