Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Total metabolic tumor volume as a prognostic biomarker in high-burden follicular lymphoma: A systematic review and meta-analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

JCJuhi ChovatiyaSVSaai Poornima VommiAJAkhil Jain

Discussion

Loading...

Member takes

Overview

Systematic review reveals total metabolic tumor volume is a key prognostic biomarker for progression-free survival in follicular lymphoma, highlighting its clinical significance.

Key Points

  • Assess the prognostic importance of baseline total metabolic tumor volume in patients with high-burden follicular lymphoma.
  • Conducted a systematic review and meta-analysis of studies on total metabolic tumor volume.
  • Analyzed data from 11 studies with 2,631 patients to evaluate progression-free survival and overall survival.
  • Searched databases including PubMed, Scopus, and Web of Science.
  • High total metabolic tumor volume correlated with worse progression-free survival and overall survival.
  • The mean hazard ratio for progression-free survival was 1.91 and for overall survival was 1.78.
  • Identified the most validated cutoff for TMTV as >510 cm³.

Cite This Study

Chovatiya et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d710https://doi.org/10.1182/blood-2025-7127
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1International Benchmark for Total Metabolic Tumor Volume Measurement in Baseline 18 F-FDG PET/CT of Lymphoma Patients: A Milestone Toward Clinical Implementation2024 · 72 citations
  2. 2Prognostic value of combining beta-2-microglobulin and total metabolic tumor volume in patients with follicular lymphoma: A post-hoc analysis of the relevance trial2025
  3. 3Prognostic value of the combination of volume, massiveness and fragmentation parameters measured on baseline FDG pet in high-burden follicular lymphoma2024 · 10 citations
  4. 4Prognosis prediction beyond MTV using easy to calculate parameters derived from FDG-PET/CT, a pilot Study2025
  5. 5Performance of radiomics features in patients with peripheral T-cell lymphoma: Data from international prospective T-cell project 2.02025