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December 8, 2025BloodOpen Access

Performance of radiomics features in patients with peripheral T-cell lymphoma: Data from international prospective T-cell project 2.0

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Authors

TSTetiana SkrypetsFFFederico FallancaMRManuela Racca

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Overview

Prospective analysis reveals treatment response correlates with metabolic activity and prognosis in PTCL.

Key Points

  • To assess the prognostic value of radiomics features and treatment response in patients with peripheral T-cell lymphoma (PTCL).
  • Conducted a sub-study within the T-Cell Project 2.0 involving 138 PTCL patients from 8 centers.
  • Evaluated FDG-PET scans for tumor segmentation and calculated radiomic features like TMTV and SUVmax.
  • Performed univariate analysis to evaluate overall survival (OS) and progression free survival (PFS) with Cox regression.
  • Median follow-up was 39 months, with OS and PFS at 3 years reported as 55% and 46% respectively.
  • TMTV threshold of 200 ml stratified patients into high and low-risk groups significantly affecting OS and PFS.
  • Age, LDH, PS, and albumin levels were identified as adverse prognostic factors correlating with lower OS.

Cite This Study

Skrypets et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1fdhttps://doi.org/10.1182/blood-2025-3651
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PET imaging biomarkers predict survival in peripheral T-cell lymphoma: A systematic review and meta-analysis.2025
  2. 2Analysis of the role of baseline PET/CT in a prospective study of unselected patients: The UK MCL biobank2025
  3. 3Radiomic features from PET-CT enable diagnostic and prognostic stratification in peripheral T-cell lymphoma2025
  4. 4Total metabolic tumor volume as a prognostic biomarker in high-burden follicular lymphoma: A systematic review and meta-analysis2025
  5. 5Baseline and interim PET‐based outcome prediction in peripheral T‐cell lymphoma: A subgroup analysis of the PETAL trial2020 · 28 citations