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December 8, 2025Blood

PET imaging biomarkers predict survival in peripheral T-cell lymphoma: A systematic review and meta-analysis.

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Authors

NMNeha Mehta–ShahSaint Louis UniversityFHFrederick HagemeisterThe University of Texas MD Anderson Cancer Center

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Implication

Systematic review and meta-analysis identified PET biomarkers linked to survival in patients with peripheral T-cell lymphoma, suggesting clinical relevance.

Key Points

  • This meta-analysis evaluates the prognostic value of PET imaging biomarkers in peripheral T-cell lymphoma (PTCL).
  • Conducted systematic review and meta-analysis of 196 articles
  • Included studies on treatment-naive adults with nodal PTCL
  • Analyzed hazard ratios associated with PET biomarkers like TMTV and TLG
  • Baseline total metabolic tumor volume (TMTV) associated with inferior progression-free survival (PFS)
  • Total lesion glycolysis (TLG) indicated worse overall survival (OS)
  • Patients with high Deauville scores (DS) had improved PFS and OS outcomes

Cite This Study

Mehta‐Shah et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d300https://doi.org/10.1182/blood-2025-6299
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