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Comparison of different response evaluation criteria in interim PET/computed tomography for diffuse large B-cell lymphoma: is Δtotal metabolic tumor volume a worthwhile measure?

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Retrospective analysis evaluates survival predictors in DLBCL patients, highlighting ΔSUV max findings.

ΔSUV max is identified as the most reliable predictor of survival in patients with diffuse large b-cell lymphoma.
The study shows that ΔTMTV was significantly associated with survival outcomes, but not superior to other criteria.
Patients with high baseline TMTV had notably lower progression-free survival and overall survival rates.
The findings suggest that interim PET/CT response evaluation can improve clinical decisions, yet further refinement of metrics is necessary.

Babacan et al. (2025) studied this question.

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