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July 20, 2023Open Access

Prognostic value of metabolic parameters of baseline PET/CT in patients with double expression types of diffuse large B-cell lymphoma

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Key result

High baseline TMTV predicts ~304% higher mortality in double expression diffuse large B-cell lymphoma.

  • HR 4.042
  • 95% CI 1.445-11.312
  • P=0.008
  • n=118

Why the study?

The study was conducted to explore the value of baseline PET/CT parameters for predicting prognosis in patients with double expression lymphoma.

Population

118 patients diagnosed with DLBCL at two independent medical centers

Comparison

Baseline PET/CT metabolic parameters (SUVmax, TMTV, TLG) for predicting OS

Design

Two-center retrospective cohort study

Authors

JZJin-cheng ZhaoNanjing Drum Tower HospitalYTYue TengShanghai University of Traditional Chinese MedicineCJChong JiangNational Natural Science Foundation of China

Discussion

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Implication

Baseline PET/CT parameters may stratify DEL prognosis; leaves open incremental value beyond IPI in prospective validation.

Study Design

Type

Cohort (n=118)

Multicenter

Yes

Structured PICO

P
Population
118 patients with double expression diffuse large B-cell lymphoma, median age 62.5 years, who underwent pretreatment [18F]FDG PET/CT and were followed for overall survival.
E
Exposure
Baseline [18F]FDG PET/CT metabolic parameters (TMTV, SUVmax, TLG) and clinical risk factors (ECOG PS)
O
Outcome
Overall survival (OS), defined as the time from the date of diagnosis to the occurrence of death from any causehard clinical

Main Result

Hazard Ratio: 4.042 (95% CI 1.445–11.312)

p-value: p=0.008

Total metabolic tumor volume (TMTV) and ECOG performance status are independent predictors of overall survival in patients with double expression lymphoma, and their combination provides accurate prognostic predictions.

Limitations

  • Retrospective examination of a limited number of patients at just two centers.
  • Using SUV ≥ 2.5 as the threshold for outlining images can result in some non-tumor areas being classified as tumor areas.
  • Different reconstruction schemes, PET/CT equipment, and influencing factors can affect the accuracy of volumetric parameters.
  • Retrospective examination of a limited number of patients at just two centers
  • Using SUV ≥ 2.5 as the threshold for outlining images can result in some non-tumor areas being classified as tumor areas
  • Different reconstruction schemes, PET/CT equipment, and influencing factors can affect the accuracy of volumetric parameters

Cite This Study

Zhao et al. (2023) conducted a cohort in Double expression diffuse large B-cell lymphoma (DEL) (n=118). High total metabolic tumor volume (TMTV ≥ 230.9 cm3) vs. Low TMTV (< 230.9 cm3) was evaluated on Overall survival (OS) (HR 4.042, 95% CI 1.445-11.312, p=0.008). High baseline total metabolic tumor volume (TMTV > 230.9 cm3) independently predicted worse overall survival (HR 4.042) in patients with double expression diffuse large B-cell lymphoma.

synapsesocial.com/papers/6aa73b5d2763b0a462d3b40dhttps://doi.org/10.21203/rs.3.rs-3077425/v1
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