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December 8, 2025BloodOpen Access

Prognostic value of baseline FDG PET/CT total metabolic tumor volume and MYC/BCL2 double expression status in patients with diffuse large B-cell lymphoma

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Authors

KNKiyotaka NakajimaHokkaido University

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Implication

Retrospective analysis shows high TMTV worsens prognosis in malignant lymphoma, indicating treatment guidance for DE-DLBCL.

Key Points

  • This research assesses the prognostic significance of baseline total metabolic tumor volume (TMTV) and MYC/BCL2 expression in diffuse large B-cell lymphoma (DLBCL).
  • Conducted a retrospective study of DLBCL patients with pretreatment PET/CT evaluations.
  • Defined double-expressor lymphoma (DEL) based on MYC and BCL2 protein expression levels.
  • Analyzed outcomes using multivariable Cox proportional hazards model and Kaplan-Meier survival curves.
  • High total metabolic tumor volume (TMTV) was identified as a significant predictor of poorer progression-free survival (PFS) and overall survival (OS) in patients with DEL.
  • Median TMTV was 418 cm3, with a PFS cutoff value determined at 255.8 cm3.
  • In DE-DLBCL patients, high TMTV correlated with significantly lower PFS rates compared to low TMTV.

Cite This Study

Kiyotaka Nakajima (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e40ahttps://doi.org/10.1182/blood-2025-3660
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline PET/CT metabolic parameters in the double-expressor subtype of diffuse large B-cell lymphoma: development of a clinical–radiologic–pathologic predictive model2025
  2. 2Prognostic value of metabolic parameters of baseline PET/CT in patients with double expression types of diffuse large B-cell lymphoma2023
  3. 3Baseline and interim 18F-FDG PET/CT metabolic parameters predict the efficacy and survival in patients with diffuse large B-cell lymphoma2024 · 16 citations
  4. 418F-FDG PET/CT radiomics combined with double-expressor status enhances prognostication and high-risk stratification in DLBCL2026
  5. 5Prognostic Value of Semi-Quantitative Metabolic Parameters on [18F]FDG PET/CT in Patients with Diffuse Large B-Cell Lymphoma at Diagnosis2026