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December 8, 2025BloodOpen Access

Radiomic features from PET-CT enable diagnostic and prognostic stratification in peripheral T-cell lymphoma

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Authors

HSHajime SakumaDIDaisuke IkedaDTDaichi Terunuma

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Overview

Retrospective study shows radiomic features enhance diagnostic differentiation and prognostic stratification in peripheral T-cell lymphoma, indicating practical clinical utility.

Key Points

  • This research evaluates the diagnostic and prognostic utility of radiomic features in peripheral T-cell lymphoma (PTCL).
  • Retrospective analysis of patients diagnosed with PTCL at Kameda Medical Center.
  • Radiomic features extracted from PET-CT images to assess tumor heterogeneity.
  • LASSO logistic regression used to create diagnostic models; LASSO Cox regression for prognostic models.
  • Performance evaluated using AUC, ROC analysis, decision curve analysis, and Kaplan-Meier analysis.
  • Five radiomic features selected improved diagnostic model with AUC 0.902 (p = 0.002).
  • Two radiomic features enhanced prognostic models with significant PFS differentiation (p < 0.001).
  • Radiomics-based model showed highest predictive accuracy for progression-free survival (C-index = 0.68).

Cite This Study

Sakuma et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db06https://doi.org/10.1182/blood-2025-5333
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance of radiomics features in patients with peripheral T-cell lymphoma: Data from international prospective T-cell project 2.02025
  2. 2Exploring improved prognostication using PET/CT radiomics in relapsed/refractory, TP53-aberrant diffuse large B-cell lymphoma (DLBCL).2026
  3. 3Prognostic Value of Combined Baseline FDG PET/CT Radiomic Parameters in Primary Mediastinal B-Cell Lymphoma2026
  4. 4PET imaging biomarkers predict survival in peripheral T-cell lymphoma: A systematic review and meta-analysis.2025
  5. 5Predicting survival outcomes in CAR-t treated B-cell lymphoma by combining PET/CT imagingand clinical features2025