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December 8, 2025Blood

Outcomes of HLA-matched unrelated versus haploidentical hematopoietic cell transplantation in acute leukemia: A multicenter observational study in Brazil facilitated by the CIBMTR

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Authors

VCVergílio ColturatoICIago ColturatoGBGeorge Maurício Navarro Barros

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Overview

Observational study assesses graft-versus-host disease and survival outcomes in acute leukemia patients undergoing transplantation.

Key Points

  • To compare major hematopoietic cell transplantation outcomes between haploidentical and HLA-matched unrelated donors in acute leukemia.
  • Multicenter prospective non-randomized observational study conducted in Brazil.
  • 501 patients aged ≥18 years with acute leukemia in complete remission were included.
  • Outcomes measured included overall survival, relapse-free survival, and graft-versus-host disease incidence.
  • 66.8% received haploidentical transplants, while 33.2% received HLA-matched unrelated transplants.
  • No significant differences in overall survival or relapse-free survival rates between groups at 2 years.
  • Multivariable models showed donor type was not independently associated with any key outcomes.

Cite This Study

Colturato et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db45https://doi.org/10.1182/blood-2025-5981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HLA and non-HLA factors in haploidentical donor selection: Insights from a brazilian single-center study2025
  2. 2Matched unrelated vs. Haploidentical  donor for allogeneic stem cell transplantation in patients with acute leukemia with identical GvHD prophylaxis – a randomized prospective european trial.2025 · 2 citations
  3. 3Haploidentical and matched unrelated donor allogeneic hematopoietic stem cell transplantation offer similar survival outcomes for acute leukemia2024 · 2 citations
  4. 4Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  5. 5Matched Unrelated vs Haploidentical Donor Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide2025 · 9 citations