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This case illustrates the diagnostic and management complexities of acquired hemophilia A in an elderly patient.

December 8, 2025BloodOpen Access

Unexplained bleeding and a hidden inhibitor: A case of late-onset acquired hemophilia A

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Case report reveals complications and challenges in managing acquired hemophilia A in an elderly patient with comorbidities.

This case illustrates the diagnostic and management complexities of acquired hemophilia A in an elderly patient.
Case presentation of a 69-year-old male with various comorbidities and unexplained bleeding.
Diagnostic imaging and coagulation studies including CT scans and factor assays were performed.
Treatment involved recombinant porcine Factor VIII, NovoSeven, and immunosuppressive therapy.
Patient presented with severe anemia, isolated prolonged aPTT, and identified factor VIII inhibitor.
Hemoglobin levels stabilized and bleeding ceased following treatment and close monitoring.
Early diagnosis and treatment reduced morbidity associated with this rare disorder.

Sharma et al. (2025) studied this question.

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