Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Limited-stage Mantle Cell Lymphoma: Real-world outcomes according to nodal vs. extranodal presentation

View Full Paper
Ask AI
Bookmark
Share

Authors

DHDavid HodgsonDRDanielle RodinTATomohiro Aoki

Discussion

Loading...

Member takes

Overview

Retrospective review reveals targeted therapies improve progression-free survival in limited-stage mantle cell lymphoma patients.

Key Points

  • This study evaluates treatment patterns and outcomes in limited-stage mantle cell lymphoma based on disease presentation.
  • Conducted a retrospective review of adult patients diagnosed with stage I–II MCL
  • Categorized disease presentation as nodal or extranodal
  • Grouped treatment modalities into radiotherapy alone or chemotherapy-based regimens
  • Analyzed outcomes using progression-free survival and overall survival as endpoints
  • Employed Kaplan-Meier and Cox proportional hazards methods for statistical analysis.
  • 421 patients diagnosed with MCL; 36 with limited-stage disease
  • Nodal disease resulted in higher progression compared to extranodal disease (77% vs. 30%)
  • Patients receiving radiotherapy alone had increased progression risk compared to those on chemotherapy-based regimens (P=0.009)
  • Significant difference in progression-free survival for extranodal vs. nodal patients (not reached vs. 72 months; P=0.023)
  • Overall survival comparable between nodal and extranodal groups (228 vs. 165 months; P=0.78).

Cite This Study

Hodgson et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db89https://doi.org/10.1182/blood-2025-2769
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world treatment and safety outcomes of patients with Mantle Cell Lymphoma in the United States2025
  2. 2Early Orbital Relapse in Mantle Cell Lymphoma: Rarity, Risk, and Transplant Strategy2026
  3. 3Mantle Cell Lymphoma: A Clinicopathologic Study of 80 Cases1997 · 501 citations
  4. 4Clinicopathologic Characteristics and Survival Outcome of Patients With Mantle Cell Lymphoma: A North Indian Tertiary Care Center Experience2025 · 1 citations
  5. 5Treatment patterns and survival outcomes in patients with Mantle Cell Lymphoma: Interim report of the Asia-Pacific multinational prospective registry study2025 · 1 citations