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December 8, 2025BloodOpen Access

Etoposide + cytarabine + pegfilgrastim vs cyclophosphamide + granulocyte colony-stimulating factor for stem-cell mobilization in patients with multiple myeloma: A phase III trial

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Authors

LSLihong ShouHuzhou Central HospitalJJJie JinXi’an Jiaotong-Liverpool UniversityHJHuifang JiangChinese Academy of Agricultural Sciences

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Implication

Phase III trial demonstrates better mobilization efficiency with etoposide plus pegfilgrastim in multiple myeloma treatment.

Key Points

  • To evaluate the effectiveness and safety of the EAP regimen for stem-cell mobilization in patients with multiple myeloma.
  • Randomized controlled trial comparing EAP and CG regimens in adults with newly diagnosed multiple myeloma.
  • Patients assigned in a 2:1 ratio to EAP or CG groups based on lenalidomide exposure.
  • Assessment of patients' hematopoietic stem cell yield after apheresis sessions.
  • 83.7% of EAP patients met the optimal collection threshold after one apheresis session versus 40.9% in CG (p＜0.0001).
  • EAP patients required fewer sessions (1.1 vs. 1.6) to achieve the target yield (≥2×10⁶ CD34+ cells/kg).
  • Median cumulative CD34+ cell yield was greater in the EAP group (13.2 ×10⁶/kg) compared to CG (5.5 ×10⁶/kg) (p＜0.0001).

Cite This Study

Shou et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db9dhttps://doi.org/10.1182/blood-2025-5960
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Etoposide combined with cytarabine and pegfilgrastim for poorly mobilizing patients with multiple myeloma and lymphoma: A prospective multicentre study2024 · 8 citations
  2. 2Research Article: Cyclophosphamıde–Etoposıde + G-csf Compared to G-csf alone in Perıpheral Blood Stem Cell Mobılızatıon for Multıple Myeloma2022
  3. 3Fractionated Intermediate‐Dose Etoposide Plus G‐ CSF for Peripheral Blood Stem Cell Mobilization in Patients With Lymphoma and Multiple Myeloma Undergoing Autologous Stem Cell Transplantation: A Prospective Observational Study2026
  4. 4Efficacy and safety of stem cell mobilization with etoposide +cytarabine plus G-CSF in poor mobilizers with relapsed or refractory lymphoma2024 · 1 citations
  5. 5A randomized comparison of etoposide and cyclophosphamide for stem cell mobilization in newly diagnosed multiple myeloma2026