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April 4, 2026Scientific ReportsOpen Access

A randomized comparison of etoposide and cyclophosphamide for stem cell mobilization in newly diagnosed multiple myeloma

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Authors

YSYao SunChinese General Hospital College of Nursing and Liberal ArtsJLJieping LiUniversity of South ChinaYDYujun DongPeking University

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Implication

Randomized trial compares etoposide and cyclophosphamide effectiveness for stem cell mobilization in multiple myeloma, suggesting etoposide is preferred.

Key Points

  • To compare the efficacy of etoposide and cyclophosphamide for stem cell mobilization in newly diagnosed multiple myeloma patients.
  • Randomized, open-label, multicenter trial
  • Enrolled newly diagnosed multiple myeloma patients eligible for autologous stem cell transplantation
  • Assigned patients to high-dose etoposide or high-dose cyclophosphamide
  • Administered granulocyte colony-stimulating factor after chemotherapy
  • Etoposide group achieved higher CD34+ cell counts ≥2 × 10⁶/kg (100% vs. 77%, p = 0.011)
  • Etoposide group had more successes with CD34+ cell counts ≥5 × 10⁶/kg (90% vs. 55%, p = 0.002)
  • Etoposide group also exceeded in CD34+ counts ≥8 × 10⁶/kg (71% vs. 32.3%, p = 0.023)
  • Fewer apheresis sessions and transfusions were needed for the etoposide group
  • Less nausea was reported during mobilization with etoposide

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69d0afde659487ece0fa5fb2https://doi.org/10.1038/s41598-026-46787-1
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Comparison of etoposide combined with G-CSF and cyclophosphamide combined with G-CSF in the mobilization of autologous peripheral blood stem cells in patients with multiple myeloma].2024 · 1 citations
  2. 2Comparison of the efficiency, safety, and survival outcomes in two stem cell mobilization regimens with cyclophosphamide plus G-CSF or G-CSF alone in multiple myeloma: a meta-analysis2021 · 25 citations
  3. 3Chemomobilization with Etoposide is Highly Effective in Patients with Multiple Myeloma and Overcomes the Effects of Age and Prior Therapy2010 · 49 citations
  4. 4Peripheral Blood Progenitor Cell Mobilization for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation2014 · 208 citations