What question did this study set out to answer?

To report a case of elevated aPTT in a patient receiving prophylactic subcutaneous unfractionated heparin.

December 8, 2025Blood

Elevated aPTT in the setting of prophylactic unfractionated subcutaneous heparin administration

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Authors

AJAlexander JohnstonHenry Ford Hospital GTGrace TriskaHenry Ford Hospital

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Implication

Case report shows elevated aPTT and coagulopathy in a patient under subcutaneous heparin for venous thromboembolism, highlighting risks in chronic kidney disease.

Key Points

To report a case of elevated aPTT in a patient receiving prophylactic subcutaneous unfractionated heparin.
Case report of a 75-year-old female with kidney dysfunction on heparin prophylaxis.
Monitoring of aPTT and coagulopathy workup conducted over hospitalization.
Interventions included potassium management, hemodialysis, and protamine sulfate administration.
Patient experienced supratherapeutic aPTT > 150 seconds after 7 days on heparin.
Significant bleeding occurred, necessitating protamine sulfate and desmopressin use.
Elevated aPTT attributed to subcutaneous unfractionated heparin despite no bolus administration.

Cite This Study

Johnston et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dbbc https://doi.org/10.1182/blood-2025-6631

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Implication

Case report shows elevated aPTT and coagulopathy in a patient under subcutaneous heparin for venous thromboembolism, highlighting risks in chronic kidney disease.

Elevated aPTT in the setting of prophylactic unfractionated subcutaneous heparin administration

Discussion

Member takes

Implication

Key Points

Cite This Study

Elevated aPTT in the setting of prophylactic unfractionated subcutaneous heparin administration

Discussion

Member takes

Implication

Key Points

Cite This Study

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