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December 8, 2025Blood

Impact of COVID-19 infection on hospitalization outcomes in patients with myeloproliferative neoplasms: Analysis of the national inpatient sample 2020–2021

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Authors

EJEvani JainCSChiranjeevi SainathamPCPrashant Chaulagain

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Overview

Analysis reveals COVID-19 significantly worsens hospitalization outcomes in myeloproliferative neoplasms patients, suggesting critical care measures are needed.

Key Points

  • To analyze the impact of COVID-19 infection on hospitalization outcomes in patients with myeloproliferative neoplasms.
  • Queried National Inpatient Sample database (2020-2021)
  • Included individuals with myeloproliferative neoplasms and COVID-19
  • Primary outcomes were length of stay, hospitalization charges, and in-hospital mortality
  • Analysis of comorbidity using Charlson Comorbidity Index
  • 37,650 hospitalizations with myeloproliferative neoplasms identified, with 460 having COVID-19
  • COVID-19 group had higher odds of mortality (aOR: 2.65) and longer length of stay (aOR: 2.12)
  • Incidences of thromboembolic events like myocardial infarction (7.2% vs. 3.6%) and pulmonary embolism (6.5% vs. 3.4%) were significantly higher in COVID-19 patients

Cite This Study

Jain et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dbebhttps://doi.org/10.1182/blood-2025-7319
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A-10 | Percutaneous Coronary Intervention in Patients with Myeloproliferative Neoplasms. A Propensity-Matched Analysis of National Database2024
  2. 2Trends in the thrombotic complications of myeloproliferative neoplasms: A nationwide analysis.2024
  3. 3Non-cancer related deaths in myeloproliferative neoplasm and Myelodysplastic Syndromes : A populaton based analysis2025
  4. 4Changes in Hospitalization and Infection Burden in Patients with Multiple Myeloma Before and During the COVID-19 Pandemic2026
  5. 5Impact of essential thrombocythemia on in-hospital outcomes and thrombotic complications in patients hospitalized with COVID-19: A national inpatient sample analysis (2016–2022)2025