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December 8, 2025Blood

Non-cancer related deaths in myeloproliferative neoplasm and Myelodysplastic Syndromes : A populaton based analysis

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CYConnor Yost

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Overview

Retrospective analysis finds elevated risk of tuberculosis and vascular disease in patients with MPN and MDS, suggesting targeted interventions are needed.

Key Points

  • This research aims to characterize leading causes of non-cancer mortality in patients with myeloproliferative neoplasms and myelodysplastic syndromes.
  • Retrospective analysis of 166,785 adults diagnosed with MPN or MDS from the SEER database (2000-2022).
  • Calculated Standardized Mortality Ratios (SMRs) to compare observed non-cancer deaths to expected deaths in a matched U.S. population.
  • Stratified analyses by age, sex, race, and ethnicity regarding causes of non-cancer deaths.
  • Tuberculosis was the leading cause of non-cancer mortality (7.22 SMR).
  • Infectious diseases, including HIV, and septicemia were significant causes, with SMRs of 4.31 and 3.80, respectively.
  • Younger patients (<50 years) showed elevated vascular disease mortality (10.43 SMR), especially in American Indian/Alaska Native individuals.

Cite This Study

Connor Yost (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d19dhttps://doi.org/10.1182/blood-2025-6416
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Also Consider

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  1. 1Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025
  2. 2Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database2025
  3. 3Cause of non-cancer related death among patients diagnosed with lymphoid neoplasm: A SEER-based study2025
  4. 4Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study2025 · 1 citations
  5. 5Longitudinal trends (1999–2023) and forecasted mortality (2024–2030) in sepsis-associated mortality among patients with Myelodysplastic Syndromes in the United States.2025