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December 8, 2025BloodOpen Access

Clone-specific epigenetic regulatory mechanisms in ASXL1-mutant chronic myelomonocytic leukemia

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Authors

TLTerra L. LashoAMAmelia MazzoneCFChristy Finke

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Overview

This research demonstrates chromatin accessibility in chronic myelomonocytic leukemia, suggesting epigenetic therapies may improve outcomes.

Key Points

  • This study aims to investigate the epigenetic mechanisms in ASXL1-mutant chronic myelomonocytic leukemia (CMML).
  • Conducted bulk RNA-seq and ChIP-seq on bone marrow cells from CMML patients
  • Performed differential analyses of gene expression and histone modifications
  • Investigated chromatin accessibility using GoT-ChA-seq
  • Conducted in vitro colony forming assays with a dual p300/BRD4 inhibitor EP31670
  • Identified key histone modifications linked to leukemogenic driver genes
  • Observed differential chromatin accessibility between ASXL1-mutant and wildtype cells
  • EP31670 showed preferential therapeutic effects in ASXL1-mutant samples at low concentrations

Cite This Study

Lasho et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc66https://doi.org/10.1182/blood-2025-234
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