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December 8, 2025Blood

Epigenetic dysregulation of the polycomb axis in Acute Myeloid Leukemia: Clinical and prognostic correlates

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Authors

JEJessica El‐AsmarDNDaniel Paul NurseZTZhengkai Tu

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Overview

Retrospective study reveals polycomb mutations affect treatment outcomes in acute myeloid leukemia, suggesting prognosis variability.

Key Points

  • To describe the clinical and prognostic features of mutations in the polycomb axis in acute myeloid leukemia.
  • Conducted a retrospective cohort study evaluating patients with AML carrying mutations in polycomb genes.
  • Collected data on demographics, molecular profiles, treatments, and outcomes.
  • Applied Kaplan-Meier analysis and multivariable regression models to assess survival outcomes.
  • Among 971 patients, mutations in polycomb genes were prevalent, impacting clinical features and survival.
  • ASXL1 and BCOR mutations correlated with distinct demographics but not significantly with treatment response.
  • SUZ12 mutations showed potential for improved treatment response and median overall survival.

Cite This Study

El‐Asmar et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e295https://doi.org/10.1182/blood-2025-7035
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic relevance of mutational profile in secondary Acute Myeloid Leukemia patients treated with CPX-351.2025
  2. 2Clinical significance of RAS-MAPK pathway mutations in Acute Myeloid Leukemia: Insights from a retrospective cohort2025
  3. 3Prevalence and Prognostic Impact of ASXL1 Somatic Mutation in Patients with Chronic Myeloid Leukemia: A Systematic Review and Meta-Analysis2026
  4. 4Spliceosome mutations in AML: Prevalence, clinical features, and treatment outcomes in a contemporary cohort2025 · 1 citations
  5. 5Prognostic impact of ASXL1 somatic mutation on patients with chronic myeloid leukemia: A systemic review and meta-analysis.2026