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December 8, 2025BloodOpen Access

Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis

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Authors

JXJane J XuAFAlexander FischerEUEno-obong Udoh

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Overview

Research reveals STAG2 mutation increases hematopoietic stem cells and alters chromatin structure, suggesting pathways for leukemia treatment.

Key Points

  • This research examines the role of STAG2 mutations in hematopoietic stem cell differentiation and leukemogenesis.
  • Utilized low-input Hi-C to analyze chromatin structures in LSK and GMP populations.
  • Performed ATACseq to assess chromatin accessibility changes related to STAG2 mutations.
  • Conducted FLI1 Cut&Run to evaluate FLI1 binding dynamics in mutant KOs.
  • STAG2 loss leads to increased hematopoietic stem cell markers like CD34.
  • Mutation promotes altered chromatin accessibility, particularly affecting early myeloid specification.
  • FLI1 was identified as a key transcription factor enhanced by STAG2 mutation in leukemia models.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcbbhttps://doi.org/10.1182/blood-2025-1467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation2025
  2. 2STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia2024 · 27 citations
  3. 3ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia2025
  4. 4Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome2025
  5. 5Activation of endogenous retroviral elements drives inflammation and transformation in STAG2-mutant myeloid malignancies2025 · 1 citations