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December 8, 2025Blood

ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia

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Authors

LZLeying ZhangCity Of Hope National Medical CenterJIJihyun IrizarryCity Of Hope National Medical CenterJAJennifer Rangel AmbrizCity Of Hope National Medical Center

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Overview

Findings reveal ST2 promotes leukemia transformation and immune evasion in AML, suggesting targeting ST2 may enhance treatment efficacy.

Key Points

  • The research examines the role of ST2 in promoting leukemia progression and reshaping the immune environment in Acute Myeloid Leukemia (AML).
  • Utilized a conditional Cbfb::MYH11 (CM) murine model of AML to study ST2 effects.
  • Employed scRNA-seq and flow cytometry to assess ST2 expression and immune cell interactions.
  • Conducted genetic knockout studies using CM-ST2-KO mice to evaluate leukemia onset and survival.
  • Analyzed cell-cell communication and gene expression associated with immune suppression.
  • ST2 upregulation was identified as a critical factor in AML progression and immune evasion.
  • CM-ST2-KO mice exhibited delayed leukemia onset and improved survival compared to CM mice.
  • Cell-cell communication analysis revealed increased interactions between leukemic cells and immune populations regulated by ST2.
  • Key immune suppressive markers, including PD-L1 and ALOX5, were upregulated in CM mice and reversed in CM-ST2-KO mice.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d77fhttps://doi.org/10.1182/blood-2025-1459
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 198: The IL-33/ST2 signaling reshapes the immune landscape and promotes leukemia transformation in acute myeloid leukemia.2026
  2. 2STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation2025
  3. 3Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis2025
  4. 4Characterising the leukaemic microenvironment in a mouse model of infant AML with prenatal KMT2A-MLLT3 expression2025
  5. 5Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia2024 · 5 citations