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December 8, 2025BloodOpen Access

Cd39 overexpression in AML blasts elicits an immune suppressive bone barrow microenvironment via G3/G4 neutrophils and Th1 cells

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Authors

HMH. MaiJYJinming Yu

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Overview

Transcriptomic profiling reveals Cd39 promotes neutrophil expansion and immunosuppression in bone marrow, suggesting targeted therapies may enhance anti-leukemic efficacy.

Key Points

  • To investigate how Cd39 overexpression in AML blasts affects the bone marrow microenvironment and immune cell interactions.
  • Used TIB-49 AML cell line modified to overexpress Cd39 and labeled for tracking
  • Conducted single-cell RNA sequencing and flow cytometry analyses on bone marrow cells from leukemic mice
  • Performed transcriptomic profiling to assess neutrophil population shifts in bone marrow
  • Increased neutrophil proportions and specific G3/G4 subpopulations were observed in Cd39 overexpressing mice
  • Identified key mechanisms like Spp1-Cd44 and Clec2d-Cd161 interactions driving immunosuppression
  • Neutrophil extracellular trap formation pathways were upregulated while T cell responses were downregulated, indicating immune suppression

Cite This Study

Mai et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcbdhttps://doi.org/10.1182/blood-2025-1469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD39 defines an exhausted effector memory T cell subset associated with poor outcome in Acute Myeloid Leukemia: Immunophenotypic and transcriptomic analysis2025
  2. 2Abstract 7413: CD36 influences leukemia progression in MLL-AF9-driven AML by modulating the leukemia immune microenvironment2026
  3. 3Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia2023
  4. 4Leukocyte immunoglobulin-like receptor subfamily B member 1 expression defines CD8+ T cell exhaustion in acute myeloid leukemia2026
  5. 5CD39-associated myeloid-T-cell coordination within an immunoregulatory neighborhood linked to treatment resistance in triple-negative breast cancer2026