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December 8, 2025Blood

Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia

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Authors

KKKohei KumeRSRongchen ShiMRMark E. Robinson

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Overview

Time-lapse imaging reveals that alternating cell states enhance leukemia-initiating capacity in acute lymphoblastic leukemia, suggesting critical regulatory dynamics.

Key Points

  • To elucidate the role of cell state transitions in stemness and leukemia initiation in acute lymphoblastic leukemia.
  • Performed time-lapse imaging of patient-derived B-ALL cells
  • Conducted gene expression studies on proliferative and quiescent states
  • Utilized CRISPR and HDRT for engineering B-ALL cells with dual-reporter knockin alleles
  • Engaged in multiplex immunofluorescence on patient samples for spatial analysis
  • B-ALL cells displayed alternating cycles of proliferative and quiescent states
  • MYC-driven and BCL6-driven gene expression programs characterized different cell states
  • Alternating cells exhibited critical leukemia-initiating potential, unlike MYC-only cells

Cite This Study

Kume et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcd5https://doi.org/10.1182/blood-2025-1485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4758: MYC-BCL6 state transition drives metabolomic cycling and leukemia-initiating capacity in B-ALL2026
  2. 2Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025 · 2 citations
  3. 3Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025
  4. 4Abstract B035: Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025
  5. 5Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia2025