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December 8, 2025BloodOpen Access

Thyroid diffuse large B-cell lymphoma in China: Multicenter study of diagnosis, clinical features, treatment efficacy, prognostic factors, and genomic alterations

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Authors

HSHao SunNanchang UniversityGCGuohui CuiHuazhong University of Science and TechnologySYShenmiao YangPeking University

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Overview

Multicenter study reveals treatment efficacy and key prognostic factors in thyroid diffuse large B-cell lymphoma.

Key Points

  • To investigate the characteristics and treatment outcomes of thyroid diffuse large B-cell lymphoma.
  • Conducted a multi-center retrospective analysis of 190 TDLBCL patients across 22 institutions in China.
  • Analyzed clinicopathological data, treatment modalities, and survival outcomes.
  • Performed targeted sequencing on 49 tumor samples to identify mutational patterns.
  • Primary TDLBCL patients showed improved overall response rates and survival outcomes compared to secondary cases.
  • Key adverse prognostic factors include elevated LDH, Ann Arbor stage III–IV, and maximum tumor diameter ≥6 cm.
  • Genomic profiling identified common mutations in TP53 and TET2 but no significant survival associations.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd75https://doi.org/10.1182/blood-2025-1902
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