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December 8, 2025Blood

Real-world treatment patterns and outcomes of patients with myelodysplastic syndrome by line of therapy

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Authors

JAJacob AmbroseABAndrew J. BelliCZChristina M. Zettler

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Overview

Observational study shows low response rates and worse outcomes in high-risk patients with myelodysplastic syndrome, indicating a need for new therapies.

Key Points

  • This research aims to characterize the treatment patterns and outcomes of patients with myelodysplastic syndrome (MDS) in real-world settings.
  • Retrospective observational study utilizing the COTA real-world database from electronic health records
  • Included MDS patients diagnosed between 2015 and 2023 who received first-line treatment
  • Evaluated progression-free survival and overall survival using Kaplan-Meier method
  • Median follow-up was 54.1 months with 1,429 patients analyzed
  • Response rate to first-line therapy was 31.1% and decreased significantly for later lines of therapy
  • Higher International Prognostic Scoring System scores correlated with worse outcomes in survival and treatment response

Cite This Study

Ambrose et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd82https://doi.org/10.1182/blood-2025-601
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Also Consider

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  1. 1Treatment patterns and overall survival among patients with myelodysplastic syndromes treated in the US community oncology setting: a real-world retrospective observational study2025
  2. 2Real-world patient characteristics, treatment patterns, and outcomes in patients with myelodysplastic syndromes2025
  3. 3Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience2025
  4. 4P51 | EVOLVING ATTRITION RATES IN MULTIPLE MYELOMA REAL-WORLD PRACTICE OVER A 30-YEARS PERIOD FROM A SINGLE CENTER EXPERIENCE2026
  5. 5Trends on treatment patterns in patients with newly diagnosed AML: Preliminary findings from a real-world analysis.2024