Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 13, 2025Leukemia & lymphoma/Leukemia and lymphomaOpen Access

Treatment patterns and overall survival among patients with myelodysplastic syndromes treated in the US community oncology setting: a real-world retrospective observational study

View Full Paper
Ask AI
Bookmark
Share

Authors

RLRoger M. LyonsYXYanqing XuCBCherrishe Brown‐Bickerstaff

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows treatment choices affect overall survival in myelodysplastic syndromes, suggesting a need for novel therapies.

Key Points

  • The aim is to evaluate treatment patterns and survival outcomes in patients with myelodysplastic syndromes (MDS) in a real-world setting.
  • Retrospective observational study using EHR data from 2,736 adult MDS patients.
  • Diagnosis confirmed between January 2011 and January 2021.
  • Treatment patterns analyzed across different IPSS-R categories.
  • 61.7% of patients initiated 1 L treatment, with higher initiation in higher-risk patients.
  • Median overall survival (OS) was 22.5 months for higher-risk versus 67.2 months for low-risk patients.
  • Low utilization (∼10%) of allogenic hematopoietic stem cell transplant among higher-risk patients.

Cite This Study

Lyons et al. (2025) studied this question.

synapsesocial.com/papers/6941aaa70f5af7fd17df4c75https://doi.org/10.1080/10428194.2025.2594059
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment patterns and outcomes in patients with myelodysplastic syndromes treated with hypomethylating agents: a SEER-Medicare analysis2021 · 16 citations
  2. 2Genetics of progression from MDS to secondary leukemia2020 · 173 citations
  3. 3Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy2010 · 280 citations
  4. 4Revised International Prognostic Scoring System for Myelodysplastic Syndromes2012 · 3,196 citations