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December 8, 2025BloodOpen Access

Multidimensional profiling of dendritic cell and monocyte subsets in sickle cell anemia: Correlation with clinical and inflammatory parameters

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Authors

FCFernando Ferreira CostaUniversidade Estadual de Campinas (UNICAMP)

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Implication

Multiparametric analysis correlates dendritic cell and monocyte subsets with inflammatory cytokines in sickle cell anemia, suggesting immune response involvement.

Key Points

  • To investigate the heterogeneity and activation profiles of dendritic cells and monocytes in sickle cell anemia.
  • Analyzed dendritic cells and monocytes from PBMCs of SCA patients and health controls using multiparametric flow cytometry.
  • Examined correlations between cell subsets and clinical parameters, including inflammatory cytokines.
  • Unsupervised analysis divided DC populations into multiple clusters based on activation status.
  • Type 1 conventional DCs were significantly reduced in SCA patients.
  • A specific pDC subset was significantly increased, indicating enhanced activation in SCA.
  • Bilirubin levels correlated with inflammatory DC frequency and CD86 expression, linking immune response to disease severity.

Cite This Study

Fernando Ferreira Costa (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236dde6https://doi.org/10.1182/blood-2025-2933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distinct dendritic cell subsets are associated with immune dysfunction and clinical severity in sickle cell anemia2026
  2. 2Innate immune dysregulation in monocytes in sickle cell disease2025
  3. 3Monocyte–red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia2025 · 1 citations
  4. 4Peripheral blood dendritic cell subtype alterations in polycythemia vera: Clinical correlations with disease risk and inflammatory profile2025
  5. 5Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Artery Disease2024 · 16 citations