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December 8, 2025BloodOpen Access

Innate immune dysregulation in monocytes in sickle cell disease

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Authors

SHSarah HindersteinSMSubhasis MohantyIMIrene Matos

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Overview

Investigating TLR responses and cytokine production in sickle cell disease monocytes, indicating immune dysregulation.

Key Points

  • This research aims to investigate TLR function in monocytes from sickle cell disease patients.
  • Isolated peripheral blood mononuclear cells from patients with sickle cell disease and healthy controls.
  • Assessed monocyte subsets and cytokine production using flow cytometry.
  • Monocytes were stimulated with lipoteichoic acid, lipopolysaccharide, and Resiquimod for analysis.
  • Sickle cell disease patients showed altered proportions of classical and non-classical monocytes.
  • Increased IL-6 production in classical monocytes from sickle cell disease patients following stimulation with TLR agonists.
  • Trends toward heightened inflammatory responses in monocytes from sickle cell disease patients were observed.

Cite This Study

Hinderstein et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e48ehttps://doi.org/10.1182/blood-2025-1155
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Also Consider

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  1. 1Characterizing the Immature Immunophenotype of Sickle Cell Disease Monocytes2024 · 1 citations
  2. 2Multidimensional profiling of dendritic cell and monocyte subsets in sickle cell anemia: Correlation with clinical and inflammatory parameters2025
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  4. 4Downregulation of cytokine responses and STAT signaling in children with sickle cell disease2026
  5. 5Impaired phagocytosis and oxidative respiratory burst activity in sickle cell anemia leukocytes2024 · 2 citations