What type of study is this?

This is a Cohort Study study (also classified as: In Vitro Study, Validation Study).

What question did this study set out to answer?

This research aims to define the variability in sickle cell trait phenotype through clinical and laboratory assessments.

December 8, 2025BloodOpen Access

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Prospective study identifies RBC deformability changes in sickle cell trait, suggesting risks for complications such as renal disease.

This research aims to define the variability in sickle cell trait phenotype through clinical and laboratory assessments.
Conducted a prospective multi-center study with a target enrollment of 700 individuals with sickle cell trait.
Included clinical surveys, laboratory tests such as CBC and urinalysis, and RBC enzyme analyses.
Assessed RBC deformability using modified Lorrca under hypoxic conditions.
5% of individuals with sickle cell trait showed sickling in the Lorrca under standard conditions; this increased to 25% under modified conditions.
33% of subjects co-inherited α-globin gene abnormalities, correlating with differences in RBC sickling.
Co-inheritance of α-globin deletions was linked to lower hemoglobin and decreased hemolysis markers.

Madisetti et al. (2025) studied this question.

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