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This research aims to analyze the biophysical characteristics of red blood cells in individuals with sickle cell trait.

December 8, 2025BloodOpen Access

Biophysical characterization of red blood cells in sickle cell trait reveals heterogeneous and intermediate pathophysiological profiles

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Biophysical profiling reveals elevated RBC occlusion and adhesion in sickle cell trait, indicating potential risks under hypoxia and inflammation.

This research aims to analyze the biophysical characteristics of red blood cells in individuals with sickle cell trait.
Utilized microfluidic platforms to assess RBC deformability and adhesion under various conditions.
Analyzed RBC properties from individuals with sickle cell trait and compared them to healthy and sickle cell anemia controls.
Measured hemoglobin-oxygen affinity using a novel optical dissociation assay and analyzed clinical markers.
RBCs from sickle cell trait showed higher microvascular occlusion under hypoxia than healthy controls.
Adhesion levels in sickle cell trait RBCs increased significantly compared to healthy controls in both normoxic and hypoxic conditions.
Considerable variability in RBC biophysical profiles among sickle cell trait individuals was noted, with implications for microvascular complications.

Mohan Madisetti (2025) studied this question.

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Biophysical profiling reveals elevated RBC occlusion and adhesion in sickle cell trait, indicating potential risks under hypoxia and inflammation.