Single-cell analysis reveals distinct γ-globin expression profiles in sickle cell disease with pancellular fetal hemoglobin

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1The German sickle cell disease registry reveals a surprising risk of acute splenic sequestration and an increased transfusion requirement in patients with compound heterozygous sickle cell disease <scp>HbS</scp>/β‐thalassaemia and no or low <scp>HbA</scp> expression2024 · 4 citations
2. 2Mean corpuscular hemoglobin modulates HbF distribution and sub-phenotypes of sickle cell disease2025
3. 3Coinheritance of non‐deletional hemoglobin H disease with sickle cell trait2024
4. 4Biophysical characterization of red blood cells in sickle cell trait reveals heterogeneous and intermediate pathophysiological profiles2025
5. 5Genetic Analysis of Two Patients with Compound Thalassemia Presenting with Elevated HbF and Normal HbA ₂ Levels2026