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December 8, 2025BloodOpen Access

Genetic variants and hemoglobinopathies among Indian sickle cell disease patients: A systematic review

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Authors

NYNagateja YedidaJawaharlal Nehru Technological University, KakinadaSPSonalika PittaKakatiya UniversitySAS. AkkineniPiedmont Athens Regional

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Implication

Systematic review identifies genetic variants, hemoglobin profiles, and disease severity in sickle cell disease patients, highlighting implications for treatment and genetic screening.

Key Points

  • To systematically review genetic variants and their effects on hemoglobin profiles and disease severity in Indian Sickle Cell Disease patients.
  • Conducted systematic search of PubMed, Scopus, and Web of Science
  • Included studies reporting molecular and hematologic data from Indian patients with Sickle Cell Disease
  • Analyzed correlations between genetic variants and clinical outcomes
  • Identified Arab-Indian haplotype as predominant in Indian SCD associated with elevated fetal hemoglobin levels
  • 27-30% of cases displayed co-inherited α-thalassemia, reducing hemolysis and anemia
  • Higher HbF levels correlated with specific genetic variants in BCL11A and Xmn1, beneficial for clinical outcomes.

Cite This Study

Yedida et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de04https://doi.org/10.1182/blood-2025-4735
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unraveling the genetic landscape of sickle cell disease in India: A literature review2026
  2. 2Epidemiology and Clinical Impact of Sickle Cell Disease in India: Genetic Diversity, Regional Inequities, And Contemporary Management Approaches - A Review2026
  3. 3Clinical heterogeneity of sickle cell disease in Indian subcontinent2026
  4. 4Identification of Sickle Cell Disease and Its Associated Other Structural Variants of Hemoglobin Using High Performance Liquid Chromatography and Their Clinical Profiling2026 · 1 citations
  5. 5Hemoglobin variants in India: A referral center-based descriptive analysis using high-performance liquid chromatography2026