What question did this study set out to answer?

The research aims to identify sickle cell disease-related hemoglobin variants and their clinical profiles in a specific population.

February 2, 2026Hemoglobin

Identification of Sickle Cell Disease and Its Associated Other Structural Variants of Hemoglobin Using High Performance Liquid Chromatography and Their Clinical Profiling

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The study identifies hemoglobin variants associated with sickle cell disease in a tribal population, suggesting important clinical implications.

The research aims to identify sickle cell disease-related hemoglobin variants and their clinical profiles in a specific population.
Screened over 1,200 individuals positive for sickle cell disease symptoms.
Conducted complete blood count analysis to identify abnormal hemoglobin levels.
Used alkaline electrophoresis and high performance liquid chromatography for confirmation of hemoglobin variants.
Identified hemoglobin variants and conducted clinical profiling based on demographic data.
Identified HbSS (21.26%), HbSF (11.39%), and HbAS (63.73%) among hemoglobin variants.
Detected 99 β-variants, 115 α-variants, 12 tetramers, and 8 δβ-hybrid Hb variants.
Found that females aged 21-30 years exhibited the highest frequency of sickle cell disease.

Kumar et al. (2026) studied this question.

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The study identifies hemoglobin variants associated with sickle cell disease in a tribal population, suggesting important clinical implications.