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December 8, 2025BloodOpen Access

Induction mortality in acute leukemia: The hidden burden of infections in a middle-income country

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AMAnaly Mora

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Overview

Retrospective cohort study finds 10.4% induction mortality in acute leukemia adults, highlighting infection challenges in middle-income settings.

Key Points

  • To estimate induction-related mortality and identify factors associated with death in acute leukemia patients.
  • Retrospective cohort study of adults with newly diagnosed acute leukemia in Mexico City
  • Collect data on demographics, clinical factors, and treatment-related aspects from medical records
  • Perform logistic regression to identify factors associated with mortality during induction phase.
  • Overall induction mortality was 10.4%, with infections leading to 74.3% of deaths.
  • Increased mechanical ventilation and fluctuating ICU admissions across periods was observed.
  • Age ≥45 and AML diagnosis were strongly associated with higher induction mortality.

Cite This Study

Analy Mora (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de5chttps://doi.org/10.1182/blood-2025-1545
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