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December 8, 2025BloodOpen Access

Hematologic predictors of serious infection and impact of serious infection on long-term mortality in AML patients: Insights from propensity-matched real-world cohorts

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Authors

KMKiran Sankar Maiti

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Overview

Retrospective analysis reveals serious infections increase mortality risk in AML patients receiving chemotherapy and hypomethylating agents, suggesting need for early identification of risk factors.

Key Points

  • This analysis aims to identify hematologic predictors of serious infections and assess their impact on long-term mortality in AML patients.
  • Retrospective multicenter Real-World Evidence analysis using TriNetX Global Network data.
  • Included 9,510 adult AML patients receiving chemotherapy or hypomethylating agents.
  • Applied propensity score matching to control for confounding, resulting in matched cohorts of 3,900 each.
  • Patients with serious infections had significantly higher rates of neutropenia and thrombocytopenia.
  • Three-year mortality was 53.8% in those with infections versus 42.6% without, indicating increased risk.
  • Risk difference for mortality associated with infections was 0.113, with a risk ratio of 1.265 and odds ratio of 1.574.

Cite This Study

Kiran Sankar Maiti (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf8dhttps://doi.org/10.1182/blood-2025-2849
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