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December 8, 2025BloodOpen Access

National analysis of real-world racial and ethnic disparities in mortality, complications, and healthcare costs among adults hospitalized with newly diagnosed Acute Myeloid Leukemia

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Authors

MÖMevlüt ÖzmenCentegra Hospital McHenryLNLavanya NagarajanRosalind Franklin University of Medicine and ScienceASAditya SureshCentegra Hospital McHenry

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Implication

Retrospective cohort analysis reveals disparities in AKI and healthcare costs among hospitalized adults with AML, suggesting urgent quality improvement needs.

Key Points

  • To analyze racial and ethnic disparities in in-hospital complications and outcomes among adults hospitalized with newly diagnosed AML.
  • Conducted a retrospective cohort study using the National Inpatient Sample (2018–2020)
  • Included all newly diagnosed AML hospitalizations regardless of treatment status
  • Analyzed outcomes like mortality, AKI, MV, and hospital costs
  • Stratified data by age and assessed for hospital-level effect modification
  • Used multivariable logistic and linear regression to adjust for demographics and comorbidities.
  • Identified 74,595 hospitalizations for newly diagnosed AML with significant racial differences in outcomes
  • Black patients showed higher AKI and hospital costs compared to White patients
  • Hispanic patients had lower AKI but higher transfusion rates
  • Other races experienced higher mortality and complications, particularly in older adults
  • Disparities varied by hospital context, being more pronounced in urban non-teaching hospitals.

Cite This Study

Özmen et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de2bhttps://doi.org/10.1182/blood-2025-6397
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inpatient outcomes in acute myeloid leukemia: A contemporary national study.2026
  2. 2Racial disparities in pediatric patients with acute myeloid leukemia.2024
  3. 3Abstract 5429: REAL-AML: Real-world predictors of early mortality and treatment inequities in acute myeloid leukemia across a multi-institutional U.S. cohort.2026
  4. 4Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  5. 5Predictors of early mortality in Acute Myeloid Leukemia: A population based analysis using SEER data.2025