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December 8, 2025BloodOpen Access

Predictors of early mortality in Acute Myeloid Leukemia: A population based analysis using SEER data.

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Authors

AIAhmad IftikharIKImran Khan

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Overview

Retrospective cohort analysis reveals chemotherapy and age influence early mortality in acute myeloid leukemia patients, suggesting intervention opportunities.

Key Points

  • This research aims to identify predictors of early mortality in patients diagnosed with acute myeloid leukemia using national cancer registry data.
  • Retrospective cohort analysis of the SEER 8 database from 1975 to 2022
  • Included patients with non-M3 AML diagnosed with specific ICD-O-3 histology codes
  • Evaluated early mortality within one and two months of diagnosis using binary logistic regression analysis.
  • Among 37,835 patients, early mortality occurred in 33.4% within one month
  • Chemotherapy significantly reduced early mortality compared to those who did not receive treatment
  • Older age was strongly associated with higher odds of early mortality.

Cite This Study

Iftikhar et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e464https://doi.org/10.1182/blood-2025-1632
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5429: REAL-AML: Real-world predictors of early mortality and treatment inequities in acute myeloid leukemia across a multi-institutional U.S. cohort.2026
  2. 2Determinants of early mortality following induction chemotherapy in Acute Myeloid Leukemia: Experience from a comprehensive cancer center in Latin America2025
  3. 3National analysis of real-world racial and ethnic disparities in mortality, complications, and healthcare costs among adults hospitalized with newly diagnosed Acute Myeloid Leukemia2025
  4. 4Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients2024 · 2 citations
  5. 5Temporal improvements in survival with persistent disparities in acute myeloid leukemia: a two-decade population-based analysis from the United States2026