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April 1, 2026Leukemia & lymphoma/Leukemia and lymphoma

Temporal improvements in survival with persistent disparities in acute myeloid leukemia: a two-decade population-based analysis from the United States

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Authors

MPManas PustakeTexas Tech UniversityJOJohnny OdehTexas Tech UniversityAHAvi HarisinganiMacNeal Hospital

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Overview

A retrospective cohort study examines survival trends in acute myeloid leukemia, highlighting persistent disparities among populations.

Key Points

  • This analysis investigates survival improvements in acute myeloid leukemia across time while examining equity among different populations.
  • Conducted a retrospective cohort study using the SEER database.
  • Included 69,551 patients aged 15 and older diagnosed with AML from 2000 to 2021.
  • Evaluated overall survival and disease-specific survival across different diagnostic periods.
  • Calculated restricted mean survival time at 60 months and employed multivariable cox regression for analysis.
  • Overall survival RMST60 improved from 15.7 months in 2000-2004 to 19.5 months in 2015-2019.
  • Median overall survival increased from 5 months to 8 months during the study period.
  • Age 65 years and older was found to be the strongest adverse prognostic factor.
  • Receipt of chemotherapy and higher income were associated with better survival outcomes.
  • Persistent disparities were noted, particularly with Black race linked to worse overall survival.

Cite This Study

Pustake et al. (2026) studied this question.

synapsesocial.com/papers/69ccb7b016edfba7beb89c2ahttps://doi.org/10.1080/10428194.2026.2643750
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved overall survival in acute myeloid leukemia over the last 15 years.2024 · 3 citations
  2. 2Improved overall survival in acute myeloid leukemia over the last 15 years2026
  3. 3Population-Level Survival Trends in Hematologic Malignancies: A Surveillance, Epidemiology, and End Results (SEER) Analysis of 494,244 Patients From 2000 to 20202026
  4. 4Improved outcomes in 17,908 acute myeloid leukemia patients across last three decades: Results from the multinational pethema registry2025
  5. 5Impact of sociodemographic factors on survival outcomes in chronic myeloid leukemia in the United States: A time-trend analysis2025