What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

This research examines the changes in treatment approaches and patient outcomes in acute myeloid leukemia over 30 years.

December 8, 2025Blood

Improved outcomes in 17,908 acute myeloid leukemia patients across last three decades: Results from the multinational pethema registry

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Authors

JMJosé MarizInstituto Português de Oncologia Francisco Gentil JBJuan Miguel Bergua BurguésHospital San Pedro de Alcántara MAMaría Luz AmigoHospital General Universitario Morales Meseguer

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Implication

Multinational analysis reveals improvements in overall survival in acute myeloid leukemia, indicating effective targeted therapies and treatment evolution.

Key Points

This research examines the changes in treatment approaches and patient outcomes in acute myeloid leukemia over 30 years.
Retrospective analysis using the PETHEMA registry data of 17,908 adult patients with newly diagnosed acute myeloid leukemia.
Patients categorized into three eras based on treatment advancements: 1990-2006, 2007-2016, 2017-2024.
Survival analyses applied using Kaplan-Meier and Cox regression methods.
Overall survival significantly improved from 9.3 months in earlier eras to 12.8 months in 2017-2024 (p<0.001).
Increased use of targeted therapies including venetoclax and hypomethylating agents in treatment regimens.
Shifts in transplant practices with more allogeneic transplants compared to autologous transplants.

Cite This Study

Mariz et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5f9 https://doi.org/10.1182/blood-2025-40

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Implication

Multinational analysis reveals improvements in overall survival in acute myeloid leukemia, indicating effective targeted therapies and treatment evolution.

Improved outcomes in 17,908 acute myeloid leukemia patients across last three decades: Results from the multinational pethema registry

Discussion

Member takes

Implication

Key Points

Cite This Study

Improved outcomes in 17,908 acute myeloid leukemia patients across last three decades: Results from the multinational pethema registry

Discussion

Member takes

Implication

Key Points

Cite This Study

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