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This research aims to evaluate survival outcomes and demographic characteristics in patients with therapy-related acute lymphoblastic leukemia.

December 8, 2025Blood

Survival outcomes in therapy-related acute lymphoblastic leukemia: A population-based analysis from SEER (2000–2022)

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This research aims to evaluate survival outcomes and demographic characteristics in patients with therapy-related acute lymphoblastic leukemia.
Data extracted from SEER 17 Incidence database (2000–2022) for patients with ALL histologies diagnosed as second malignancies.
Survival outcomes analyzed using Kaplan-Meier methods and Cox proportional hazards regression.
Patients categorized by age: <40, 40–59, and ≥60 years.
2,317 patients identified with therapy-related acute lymphoblastic leukemia.
Age was a significant predictor of mortality; older patients had higher hazard ratios.
Sex, race, and ethnicity showed no independent associations with survival outcomes.

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Population-based analysis reveals age impacts survival in acute lymphoblastic leukemia, indicating a need for age-adapted treatment strategies.

Shah et al. (2025) studied this question.

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Population-based analysis reveals age impacts survival in acute lymphoblastic leukemia, indicating a need for age-adapted treatment strategies.