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December 8, 2025Blood

Outcomes after relapse for adolescent and young adult patients with ALL: Results from the Children's oncology group

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Authors

ADAlice DangXXXinxin XuNWNaomi Winick

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Overview

Retrospective analysis finds lower survival rates in adolescents and young adults with ALL post-relapse, suggesting a need for improved stratification.

Key Points

  • Examine outcomes for adolescents and young adults with acute lymphoblastic leukemia after relapse.
  • Retrospective review of patients with B- or T-ALL enrolled in twelve clinical trials.
  • Analyzed adolescent and young adult patients aged ≥15 years who relapsed.
  • Used univariate and multivariate Cox regression models to assess overall survival.
  • 12.7% of enrolled patients relapsed, with 257 being adolescents and young adults.
  • 5-year survival rate post-relapse for AYAs was 27.7% compared to 37.9% for 10-14 year-olds.
  • Isolated CNS relapse correlated with better outcomes; initial white blood cell count impacted survival.

Cite This Study

Dang et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc76https://doi.org/10.1182/blood-2025-548
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Also Consider

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  5. 5Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025