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December 8, 2025BloodOpen Access

Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges

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Authors

UKUday KulkarniSSSushil SelvarajanGJGeetha Joseph

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Overview

Retrospective analysis shows treatment outcomes in acute lymphoblastic leukemia among adolescents, indicating financial constraints impact survival.

Key Points

  • To examine treatment outcomes and challenges of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India.
  • Retrospective analysis of 506 patients diagnosed with acute lymphoblastic leukemia from 2015 to 2023.
  • Patients aged 20 to 40 treated with the modified GMALL protocol were included in the outcome assessment.
  • Immunophenotyping and RT-PCR methods analyzed disease characteristics and genetic markers.
  • 198 (75.6%) achieved morphologic complete remission after induction.
  • Estimated 5-year overall survival was 46.0% and event-free survival was 41.7%.
  • High treatment-related toxicities and financial constraints were significant factors affecting patient outcomes.

Cite This Study

Kulkarni et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d550https://doi.org/10.1182/blood-2025-6321
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Favorable survival and tolerability of the GMALL protocol in adolescents and young adults with ALL: A single-center experience2025
  2. 2Overall survival in patients with acute lymphoblastic leukemia in the aya population, treated with modified pediatric chemotherapeutic schemes, a real-life study2025
  3. 3Pediatric inspired (BFM) protocol in adolescent and young adults (AYA) with acute lymphoblastic leukemia (ALL) in India: Real‑world treatment timelines and impact of delays on survival2025
  4. 4T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults2025 · 2 citations
  5. 5Effectiveness and prognostic impact of BMI, MRD and CNS involvement in AYA patients with Philadelphia-negative ALL treated using the AYA-15 protocol: Real-world from a tertiary center in the middle east2025