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December 8, 2025BloodOpen Access

Long-term follow-up for newly diagnosed BCR::ABL1 negative B cell acute lymphoblastic leukemia from China: 10-year outcome of RJ-ALL 2014 protocol

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Authors

WLWeiyang LiuHarbin Medical UniversityWZWeiping ZhangFujian University of Traditional Chinese MedicineJWJin WangBaylor College of Medicine

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Implication

Prospective follow-up finds RJ-ALL 2014 improves survival in newly diagnosed BCR::ABL1 negative B-ALL adolescents and young adults, indicating the role of HSCT.

Key Points

  • To evaluate the long-term outcomes of the RJ-ALL 2014 protocol in patients with BCR::ABL1 negative B-cell acute lymphoblastic leukemia.
  • Conducted a prospective follow-up study in 153 newly diagnosed patients with BCR::ABL1-negative B-ALL.
  • Patients underwent intensive treatment including RJ-ALL 2014 protocol with multiple therapy regimens.
  • Event-free survival and overall survival were documented using statistical analysis.
  • The 10-year overall survival (OS) and event-free survival (EFS) rates for patients were approximately 57.2% and 50.1% respectively.
  • Adolescents and young adults had better survival rates compared to older adults.
  • HSCT was identified as the only independent protective factor affecting OS and EFS.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236dea1https://doi.org/10.1182/blood-2025-3333
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