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December 8, 2025BloodOpen Access

Favorable survival and tolerability of the GMALL protocol in adolescents and young adults with ALL: A single-center experience

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Authors

NONicola OrlovERElena RibakovskyMKMeirav Kedmi

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Overview

Single-center experience shows favorable outcomes in adolescents with ALL treated with the GMALL protocol, suggesting effective tolerability and survival rates.

Key Points

  • Assess the efficacy of the GMALL protocol for treating acute lymphoblastic leukemia in adolescents and young adults.
  • Single-center retrospective cohort study conducted on patients aged 18-40 with Ph-negative ALL.
  • Demographic and treatment-related data were collected from consecutive patients.
  • Overall survival and event-free survival were estimated using Kaplan–Meier method.
  • Thirty-eight patients treated, with a median follow-up of 36 months.
  • Three-year event-free survival was reported at 65%, with an overall survival of 73%.
  • The regimen showed favorable tolerability with a 0% death rate during induction.

Cite This Study

Orlov et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4e4https://doi.org/10.1182/blood-2025-6863
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Also Consider

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  1. 1Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025
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  5. 5T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults2025 · 2 citations