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December 8, 2025Blood

Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study

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Authors

CECaitlin W. ElgartenVFVanessa A. FabrizioAHAnurekha G. Hall

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Overview

Analysis reveals increased hazard of death for NHB children with B-ALL, indicating treatment disparities persist.

Key Points

  • This research aims to analyze survival outcomes for children with B-ALL by race/ethnicity after relapse.
  • Retrospective analysis of the ReCALL-1 cohort studying children & young adults with high-risk 1st relapse of B-ALL.
  • Included patients treated at US centers for high-risk first relapse between 2018-2022.
  • Used multivariable Cox regression models to evaluate outcomes after adjusting for social drivers of health.
  • 311 patients met inclusion criteria (41% Hispanic, 7% NHB, 46% NHW).
  • 4-year overall survival differed by race: Hispanic 59%, NHB 37%, NHW 68%.
  • NHB patients had a 2.3-fold increased hazard of death compared to NHW patients, even after adjustments.

Cite This Study

Elgarten et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d51dhttps://doi.org/10.1182/blood-2025-4525
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity2025
  2. 2Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children's Oncology Group report2025 · 2 citations
  3. 3Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials2026
  4. 4Outcomes after relapse for adolescent and young adult patients with ALL: Results from the Children's oncology group2025
  5. 5Outcomes of children treated for relapsed or refractory acute lymphoblastic leukemia: A single tertiary care center experience2024 · 3 citations