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December 8, 2025BloodOpen Access

Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity

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Authors

QKQuynh Long KhuongKBKira BonaCECaitlin W. Elgarten

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Overview

Retrospective analysis reveals NHB children face higher post-relapse mortality in AML, indicating a need for targeted interventions.

Key Points

  • This research investigates post-relapse survival outcomes in children with Acute Myeloid Leukemia (AML) by race and ethnicity.
  • Retrospective cohort analysis of 268 children with AML from 17 institutions
  • Evaluated post-relapse overall survival by race/ethnicity
  • Analyzed frontline treatment history and clinical features at relapse using Cox models
  • 3-year post-relapse overall survival was 41% overall, with NHB at 34.9%
  • NHB patients had a 64% increased hazard of death compared to NHW
  • Similar incidence of early relapse across all racial/ethnic groups, with NHB patients showing greater likelihood of favorable cytomolecular markers

Cite This Study

Khuong et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd7fhttps://doi.org/10.1182/blood-2025-602
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study2025
  2. 2Race and Ethnicity and Overall Survival in Pediatric Acute Myeloid Leukemia2026
  3. 3Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  4. 4Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children's Oncology Group report2025 · 2 citations
  5. 5Rethinking disparity in Acute Myeloid Leukemia, a new perspective in the Asian population2025