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July 26, 2026Pediatric Blood & CancerOpen Access

Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials

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Authors

MHMallorie B. HeneghanLRLindsay A. RenfroYWYue Wu

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Overview

Pooled analysis reveals no survival differences by race in children with relapsed Hodgkin lymphoma in trials.

Key Points

  • This research aims to explore whether disparities in survival by race and ethnicity exist among children and young adults with relapsed/refractory Hodgkin lymphoma in clinical trials.
  • Pooled analysis of individual-level data from CAYAs receiving therapy for relapsed/refractory Hodgkin lymphoma on COG trials (2001-2016).
  • 3-year overall survival was estimated using the Kaplan-Meier method, while Cox regression models examined associations of race and ethnicity with overall survival.
  • Among 175 CAYAs treated for relapsed/refractory Hodgkin lymphoma, the median follow-up time was 4.9 years.
  • 3-year overall survival was 82.1% (95% CI, 75.3%-87.1%), showing no significant difference by race and ethnicity (p = 0.36).
  • Cox regression showed that shorter time from diagnosis to trial enrollment (p = 0.01) and ≥2 relapses conferred worse overall survival.

Cite This Study

Heneghan et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7e0d3aea3239cd7878ahttps://doi.org/10.1002/1545-5017.70522
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children's Oncology Group report2025 · 2 citations
  2. 2Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study2025
  3. 3Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity2025
  4. 4Disparities in survival outcomes among adolescent and young adults vs adult populations with Hodgkin lymphoma: A population based SEER study2025
  5. 5Long term outcomes of older patients with classical hodgkin lymphoma: an analysis of the Texas cancer registry2025