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December 8, 2025Blood

The core role of exosomal mir-21-5p/TGF-β1-CXCL12/RANKL axis in bone marrow microenvironment remodeling in multiple myeloma and targeted intervention strategies

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Authors

LWLi WangAHAoshuang HuangJWJishi Wang

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Overview

Observations show enhanced drug resistance in multiple myeloma linked to exosomal CXCL12 and bone marrow microenvironment changes.

Key Points

  • This research explores the role of exosomal miR-21-5p and its signaling cascade in the bone marrow microenvironment of multiple myeloma.
  • Utilized patient and mouse data through multi-omics
  • Performed miRNA sequencing and LC-MS/MS analysis
  • Isolated exosomes using ultracentrifugation-SEC
  • Conducted live-cell imaging and dual-luciferase assays to assess interactions
  • Administered neutralizing antibodies and exosome-mimetic liposomes in therapeutic interventions.
  • Identified CXCL12 and drug resistance mechanisms linked to the miR-21-5p/TGF-β1 axis
  • Over 78% of mesenchymal stem cells internalized exosomes within two hours
  • In animal models, combined treatment extended survival from 34 to 71 days
  • Notable recovery of trabecular bone volume by 68% observed.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de7ehttps://doi.org/10.1182/blood-2025-2167
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow mesenchymal stem cell derived exosomal miR-361-5p reversed the effect of bortezomib on multiple myeloma2025
  2. 2MM-derived exosomes promote M2 macrophage polarization and immunosuppressive microenvironment: therapeutic opportunities2026
  3. 3Analysis of Multiple Myeloma Drug Efficacy2024 · 1 citations
  4. 4P02 | INTERACTION BETWEEN MYELOMA AND BONE MARROW MESENCHYMAL STEM CELLS2026
  5. 5CXCL7 plays a crucial role in facilitating extramedullary invasion and osteolytic damage in multiple myeloma2024