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September 10, 2025Technology and Health Care

Bone marrow mesenchymal stem cell derived exosomal miR-361-5p reversed the effect of bortezomib on multiple myeloma

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Authors

TLTianbao LinYZYun ZhangZHZhiping Hu

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Overview

Research demonstrates that miR-361-5p influences bortezomib resistance in multiple myeloma, suggesting therapeutic potential.

Key Points

  • Low expression of miR-361-5p promotes survival of U266 cells, reversing bortezomib's effects.
  • BMSCs-derived exosomal miR-361-5p impacts the PDPK1/PI3K/AKT/mTOR axis in myeloma cells.
  • Exosomal transfer of miR-361-5p may provide a new avenue to combat multiple myeloma treatment resistance.
  • Flow cytometry indicated that miR-361-5p regulates apoptosis in response to bortezomib treatment.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c1a90c54b1d3bfb60e2236https://doi.org/10.1177/09287329251350918
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