Multicentric cohort analysis shows gut microbiome metabolites may predict response to fecal microbiota transplantation in patients with acute graft-versus-host disease.
Key Points
This study investigates the impact of microbial metabolites on fecal microbiota transplantation outcomes in patients with acute graft-versus-host disease after stem cell transplantation.
Analyzed fecal samples from patients receiving fecal microbiota transplantation for steroid-refractory aGvHD.
Performed metagenomic sequencing for microbiome profiling and targeted mass spectrometry for metabolite characterization.
Integrated metabolomic and metagenomic data with clinical outcomes including overall survival and treatment response.
Identified significant differences in metabolite profiles between FMT responders and non-responders.
Higher concentrations of immune-modulatory metabolites like butyric acid and acetic acid were found in responders.
Aim to validate a metabolite signature as a predictive biomarker for FMT efficacy.